Download Abeta Peptide and Alzheimer’s Disease: Celebrating a Century by David H. Small BSc, PhD (auth.), Colin J. Barrow BSc PDF

By David H. Small BSc, PhD (auth.), Colin J. Barrow BSc (Hons),PhD, MBA, David H. Small BSc, PhD (eds.)

Abeta Peptide and Alzheimer’s illness summarizes present wisdom of beta-amyloid peptide (Aß) and its position because the significant offender in Alzheimer’s disorder (AD), proven by way of fresh advances in genetics and mind biochemistry.

Written by means of leaders within the business and educational global focusing on this speedily relocating quarter, the ebook covers primary biochemical stories at the Aß peptide, the genetic influence on Aß expression and processing, and diverse advert healing suggestions that focus on Aß. even if particularly targeting Aß and advert, there's additionally a few dialogue at the similarity and alterations of this peptide and advert with different amyloidogenic ailments, corresponding to prion illness, Parkinson’s and Huntington’s.

This e-book will basically be of curiosity to advert researchers and clinicians but in addition to researchers of alternative amyloid diseases.

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Nature, 1998. 391(6665):387-390. 166. , Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature, 1999. 398(6727):513-517. 167. , Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer’s disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport, 1997. 8(6):1537-1542. 168. , A variant of Alzheimer’s disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

216. , Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition. Nat Genet, 1997. 17(3): 263-264. 217. , Morphology and toxicity of Abeta-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer’s disease. J Biol Chem, 1996. 271(34):20631-20635. 218. , Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature, 2002. 416(6880):535-539. 219. , Assembly of A beta amyloid protofibrils: an in vitro model for a possible early event in Alzheimer’s disease.

32(11):1061-1070. 266. , Neuronal and glial calcium signaling in Alzheimer’s disease. Cell Calcium, 2003. 34(4-5):385-397. 267. , Superoxide dismutase activity in Alzheimer’s disease: possible mechanism for paired helical filament formation. Brain Res, 1989. 476(1):160-162. 268. , Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer’s disease. Am J Pathol, 1992. 140(3):621-628. 269. , Increased nuclear DNA oxidation in the brain in Alzheimer’s disease. J Neurochem, 1998. 71(5): 2034-2040.

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