Download Artificial Neural Networks by Hugh Cartwright (eds.) PDF

By Hugh Cartwright (eds.)

This quantity provides examples of the way ANNs are utilized in organic sciences and comparable parts. Chapters concentrate on the research of intracellular sorting info, prediction of the habit of bacterial groups, biometric authentication, reviews of Tuberculosis, gene signatures in breast melanoma category, use of mass spectrometry in metabolite identity, visible navigation, and computing device analysis. Written within the hugely profitable Methods in Molecular Biology sequence structure, chapters contain introductions to their respective issues, program info for either the professional and non-expert reader, and tips about troubleshooting and averting identified pitfalls.

Authoritative and functional, Artificial Neural Networks: moment Edition aids scientists in carrying on with to check synthetic Neural Networks (ANNs).

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Here, the 324-state ϕ/ψ distribution corresponds to the likelihood that residue i adopts torsion angles that fall in any of the 324 voxels, of 20° × 20° each, that make up the Ramachandran map. The ANN-predicted ϕ/ψ distribution is then used solely to search a large crystallographic database (containing 9,523 proteins, with chemical shifts added by a computational method [26]), for a pool of 1,000 heptapeptide fragments with ϕ/ψ angles that best match the 324-state ϕ/ψ distribution. These top 1,000 fragments then are further evaluated for the agreement between their computed chemical shifts and experimental values of the corresponding heptapeptide segment (i − 3 to i + 3) in the target protein.

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J Am Chem Soc 105:5948–5949 20. Cornilescu G, Delaglio F, Bax A (1999) Protein backbone angle restraints from searching a database for chemical shift and sequence homology. Berman HM, Kleywegt GJ, Nakamura H et al (2012) The Protein Data Bank at 40: reflecting on the past to prepare for the future. Markley JL, Ulrich EL, Berman HM et al (2008) BioMagResBank (BMRB) as a partner in the Worldwide Protein Data Bank (wwPDB): new policies affecting biomolecular NMR depositions. Wishart DS (2011) Interpreting protein chemical shift data.

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